Some small randomized trials have shown reductions in melanin index scores, but there are notable flaws in these trials
Standard rotation protocol alternates between deltoid (upper arm), vastus lateralis (lateral thigh), and ventrogluteal (hip) sites, allowing each location 1014 days recovery between injections
This is a particular issue for drug metabolizing enzymes, especially cytochrome P450, which are substantially downregulated [139]
Olive oil and vitamin E - reduces dryness and softens the skin, normalizes oxygen exchange and cell nutrition, smoothes the skin and makes it more elastic, does not clog pores
This approach leverages the ability of microneedles to create microchannels in the skin, facilitating the penetration and localized action of BVs active components